For Scientists

CAA Research Worldwide

The research group at the University of Calgary investigates neuroimaging biomarkers of cognitive decline in older adults with symptomatic CAA, aiming to identify new ways to diagnose and monitor CAA and to discover the mechanisms by which CAA interferes with brain function.

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Calgary team

Initiated in 1994, the CAA Research Program at Massachusetts General Hospital is focused on the development, diagnosis, and treatment of CAA. The research is divided into a clinical program that focuses on the molecular epidemiology of CAA and a laboratory program studying its pathogenesis. See for more information: https://www.angiopathy.org/.

Boston team
 

Led by Prof. Charlotte Cordonnier, the Lille Haemorrhagic Stroke research group is a multidisciplinary team, composed of clinicians and basic scientists dedicated to research on bleeding in the brain (micro and macro). Through a translational approach (animal models, clinical cohorts, and neuropathological investigations), we aim to deepen our understanding of pathophysiology and long-term consequences of bleeding in the brain. A special insight is given to acute tissue changes, interaction between CAA and cognition as well as the management of vascular risk factors (secondary prevention) after the bleeding.

The Research to Understand Stroke due to Haemorrhage (RUSH) programme at The University of Edinburgh is dedicated to improving the outcome for adults who have diseases that may cause, or have caused, stroke due to brain haemorrhage (www.RUSH.ed.ac.uk). Fundamental study designs of clinical epidemiology is the foundation of their focus on the frequency, prognosis, treatment, and pathophysiology of brain haemorrhage. CAA is one of their interests amongst the many causes of brain haemorrhage. The Lothian INtraCerebral Haemorrhage Pathology, Imaging and Neurological outcome (LINCHPIN) study has led to the Edinburgh CT and genetic diagnostic criteria for lobar ICH associated with CAA, the related Edinburgh Criteria for CAA-associated ICH Training (ECCITING), and contributions to collaborative multicentre projects such as version 2.0 of the Boston MRI diagnostic criteria for CAA.

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Edinburgh team

In addition to developing new neuroimaging tools to study sporadic CAA, the CAA research program in Leiden has a major focus on hereditary Dutch-type CAA (formerly known as HCHWA-D or the ‘Katwijkse ziekte’). See for more information: https://www.lumc.nl/org/neurologie/research/hchwad/.

Photo of the Leiden team
Leiden team

Our team is led by Prof. Ralph Martins and is located at the Patricia and Ralph Sarich Neuroscience Research Institute, Perth Western Australia. Prof. Martins is a world leader in blood-based biomarkers for Alzheimer’s disease. Our Lab has been involved in CAA research since 2011, when the Dominantly Inherited Alzheimer Network (DIAN) Observational Study was launched and our team has access to individuals with D-CAA within DIAN.

Photo of the Perth team
Perth team