Type 1 diabetes associated with a fivefold increased risk of stroke

Scientists at the Helsinki University Central Hospital, Finland, found that adults with type 1 diabetes are more likely to develop cerebral small-vessel disease, and cerebral micro-bleeds, in particular, than those without diabetes.

“Type 1 diabetes is associated with a fivefold increased risk of stroke, with cerebral small-vessel disease (SVD) as the most common etiology,” Per-Henrik Groop, MD, DMSc, FRCPE, professor of nephrology and his colleagues wrote. “Cerebral SVD in type 1 diabetes, however, remains scarcely investigated and is challenging to study in vivo per se owing to the size of affected vasculature.”

The Finnish Diabetic Nephropathy Study
Groop and colleagues analyzed data from 191 healthy younger adults with type 1 diabetes diagnosed before age 40 years (age range, 18 to 50 years; mean age, 40 years; 53% women) who presented consecutively at Helsinki University Hospital; data from 30 adults without diabetes (mean age, 38.4 years; 57% women) were used for comparison. All participants were enrolled in the Finnish Diabetic Nephropathy Study and underwent MRI to asses incidence of cerebral small-vessel disease.

Cerebral small-vessel disease
Among the type 1 diabetes cohort, 67 participants (35%) were diagnosed with cerebral small-vessel disease compared with three participants (10%) in the control group. In the diabetes group with cerebral small-vessel disease, 45 (24%) had cerebral micro-bleeds and 44 (23%) had white matter hyperintensities. The presence of albuminuria (P = .021), use of antihypertensive medication (P = .033) and higher systolic blood pressure (P = .009) were observed more often in participants with cerebral micro-bleeds; systolic BP was the only independently associated factor (OR = 1.03 for each 1-mm Hg increase; 95% CI, 1.00-1.05). Age was the only independently associated factor for white matter hyperintensities (OR = 1.11 for each 1-year age increase; 95% CI, 1.04-1.19).

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Source: Healio.com | December 31, 2018

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