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Researchers discover drug that could prevent brain cell death caused by b-amyloid

UCLA researchers have discovered a drug that blocks b-amyloid plaques from attaching to brain cells, preventing the extensive cell death. [...]
Categories: CAA

Scientists have mounted evidence for the link between APOE4 and the white matter lesions common in vascular dementia

Scientists have been trying to figure out how the apolipoprotein E4 (APOE4) allele increases a person’s risk for late-onset Alzheimer’s [...]
Categories: CAA

Immunotherapies banish amyloid from the brain

At least four anti-amyloid immunotherapies have now demonstrated the ability to clear plaques from the brain: aducanumab, gantenerumab, Lilly’s LY3002813, [...]
Categories: CAA

Vascular risk on cognitive decline is magnified in people with higher brain amyloid levels

Vascular risk factors appear to hasten the risk of cognitive decline in normal older individuals with evidence of very early [...]
Categories: CAA

Surgical instruments may spread amyloid protein linked to neurological disease

Could Aβ aggregates clinging to surgical equipment seed pathology in patients’ brains? Possibly, according to Sebastian Brandner and colleagues at [...]
Categories: CAA

Researchers reveal how the destruction of pericytes lead to white matter damage degeneration

Alzheimer’s-related brain changes could start at 40 In a mouse study, scientists at the University of Southern California (USC) in [...]
Categories: CAA

Artificial human blood vessels: a model for cerebral amyloid angiopathy?

First functional 3-dimensional CAA-model in bioengineered human vessels Can artificial blood vessels grown from human cells shed light on amyloid [...]
Categories: CAA

Video: Inside Alzheimer’s disease

Nature Neuroscience takes us inside the brain to explore the cells, molecules and mechanisms involved in the onset and progression [...]
Categories: CAA

Inflammation helps microglia clear amyloid from Alzheimer’s brains

Previously, many scientists thought that dialing down inflammation would help, but growing evidence now suggests the opposite. Neuroinflammation can both [...]
Categories: CAA

New connection identified between ApoE4 and protein build-up associated with Alzheimer’s

Researchers at the Salk Institute discovered that the enzyme HtrA1 degrades ApoE4, the strongest genetic risk factor for Alzheimer’s disease. [...]
Categories: CAA