CAA is a cerebrovascular disorder caused by the accumulation of cerebral amyloid-β (Aβ) in the tunica media and adventitia of leptomeningeal and cortical vessels of the brain. The resultant vascular fragility tends to manifest in normotensive elderly patients as lobar intracerebral haemorrhage. It is, along with Alzheimer disease, a cerebral amyloid deposition disease, a group of related conditions characterised by the accumulation of cerebral amyloid-β (Aβ) in various parts of the central nervous system. They lead to inflammation, neurotoxicity, and vascular friability, and are typically encountered in the elderly.
All aspects of cerebral amyloid angiopathy (CAA) are described by dr Yuranga Weerakkody and prof Frank Gaillard et al.:
- Clinical presentation
- Radiographic features
- Differential diagnosis